Rising Inflation and 'Higher for Longer' Interest Rates: Elevated inflation and sustained high interest rates can increase CryoPort's operating costs (e.g., fuel, labor, capital) and potentially constrain investment within the broader life sciences sector, impacting demand for specialized logistics.

Geopolitical Volatility and Global Supply Chain Disruptions: CryoPort's operations are global, making it susceptible to disruptions from geopolitical events, such as the Strait of Hormuz closure. Such events can lead to increased shipping costs, delays, and complexities in its temperature-controlled logistics.

Funding Environment for Life Sciences Startups: A slowdown or decline in funding for cell and gene therapy startups and clinical trials, which are key clients for CryoPort, could temper future growth in demand for its specialized supply chain solutions and services.